MCP-1: Function, Regulation, and Involvement in Disease
نویسندگان
چکیده
منابع مشابه
Blood Monocyte Chemotactic Protein-1 (MCP-1) and Adapted Disease Activity Score28-MCP-1: Favorable Indicators for Rheumatoid Arthritis Activity
OBJECTIVE We assessed blood pentraxin 3 (PTX3) and macrophage chemotactic factor-1 (MCP-1) levels as indicators of disease activity in rheumatoid arthritis (RA) patients, because data on disease activity score 28 (DAS28)-erythrocyte sedimentation rate (ESR) and DAS28-C-reactive protein (CRP) are still imperfect. METHODS In 111 patients with RA, we examined longitudinal and cross-sectional cor...
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Atrial natriuretic peptide (ANP) has been shown to reduce tumor necrosis factor (TNF)-induced activation of endothelial cells via inhibition of p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)B pathways. The aim of this study was to determine whether ANP is able to inhibit TNF-induced expression of monocyte chemoattractant protein-1 (MCP-1) in endothelial cells and to elucida...
متن کاملDifferential involvement of phosphoinositide 3-kinase/Akt in human RPE MCP-1 and IL-8 expression.
PURPOSE To investigate the role of the phosphatidylinositol 3-kinase (PI3K) pathway and the signal mediator AP-1 in monocyte chemotactic protein (MCP)-1 and interleukin (IL)-8 gene expression in human retinal pigment epithelial (hRPE) cells. METHODS hRPE cells were stimulated with IL-1beta and TNF-alpha and by coculturing with monocytes in the presence or absence of a series of kinase inhibit...
متن کاملInvolvement of ERK pathway in albumin-induced MCP-1 expression in mouse proximal tubular cells.
Persistent proteinuria has been indicated to be a major risk factor for the development of tubulointerstitial damage through a process of proinflammatory molecule expression. Monocyte chemoattractant protein-1 (MCP-1) was shown to contribute to recruitment of immune cells into the renal interstitium in acute and chronic renal diseases. However, the molecular mechanisms by which proteinuria caus...
متن کاملMCP-1 and CCR2 in HIV infection: regulation of agonist and receptor expression.
Monocyte chemotactic protein-1 (MCP-1) interacts with the chemokine receptor CCR2. Two CCR2 cDNAs have been described. Sequence analysis as well as Northern blotting and RNase protection with different probes revealed that the CCR2 gene is expressed in activated natural killer (NK) cells and mononuclear phagocytes as a predominant long transcript (3.4 kb) consisting of CCR2B followed by a novel...
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ژورنال
عنوان ژورنال: International Immunopharmacology
سال: 2021
ISSN: 1567-5769
DOI: 10.1016/j.intimp.2021.107598